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Publications

Find a list of my publications here. 

2020

  1. Alkawar AMM, Castellanos AJ, Carpenter MA, Hutcherson RJ, Madkhali MAO, Johnson RM, Bottomley M, Kemp MG. Insulin-like Growth Factor-1 Impacts p53 Target Gene Induction in UVB-irradiated Keratinocytes and Human Skin. Photochem Photobiol. 2020 May 16.

  2. Gabbard RD, Hoopes RR, and Kemp MG. Spironolactone and XPB: An Old Drug with a New Molecular Target. Biomolecules. 2020 May; 10(5).

  3. Choi JH, Han S, Kemp MG. Detection of the small oligonucleotide products of nucleotide excision repair in UVB-irradiated human skin. DNA Repair (Amst). 2020 Feb;86:102766. doi: 10.1016/j.dnarep.2019.102766. Epub 2019 Dec 5. PubMed PMID: 31838380; PubMed Central PMCID: PMC6960337.

  4. Travers JB, Kemp MG, Weir NM, Cates E, Alkawar AM, Mahajan AS, Spandau DF. Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin. Arch Dermatol Res. 2020 Jan;312(1):1-4. doi: 10.1007/s00403-019-02001-z. Epub 2019 Oct 28. PubMed PMID: 31659432; PubMed Central PMCID: PMC6989043.

  5. Shaj K, Hutcherson RJ, Kemp MG. ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation. Photochem Photobiol. 2020 Jan;96(1):105-112. doi: 10.1111/php.13164. Epub 2019 Oct 17. PubMed PMID: 31554014; PubMed Central PMCID: PMC6980238.

    • Note: made the cover of the journal!

2019

  1. Hutcherson RJ, Kemp MG. ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis. Mutat Res. 2019 Nov;816-818:111678. doi: 10.1016/j.mrfmmm.2019.111678. Epub 2019 Sep 17. PubMed PMID: 31557599; PubMed Central PMCID: PMC6905468.

  2. Kemp MG. Damage removal and gap filling in nucleotide excision repair. Enzymes. 2019;45:59-97. doi: 10.1016/bs.enz.2019.06.001. Epub 2019 Jul 13. Review. PubMed PMID: 31627883.

  3. Kemp MG, Krishnamurthy S, Kent MN, Schumacher DL, Sharma P, Excoffon KJDA, Travers JB. Spironolactone Depletes the XPB Protein and Inhibits DNA Damage Responses in UVB-Irradiated Human Skin. J Invest Dermatol. 2019 Feb;139(2):448-454. doi: 10.1016/j.jid.2018.07.039. Epub 2018 Sep 15. PubMed PMID: 30227140; PubMed Central PMCID: PMC6342635.

2018

  1. Poudel S, Yao J, Kemp MG, Leffak M. Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells. J Biol Chem. 2018 Sep 14;293(37):14497-14506. doi: 10.1074/jbc.RA118.004519. Epub 2018 Jul 23. PubMed PMID: 30037903; PubMed Central PMCID: PMC6139568.

  2. Khan AQ, Travers JB, Kemp MG. Roles of UVA radiation and DNA damage responses in melanoma pathogenesis. Environ Mol Mutagen. 2018 Jun;59(5):438-460. doi: 10.1002/em.22176. Epub 2018 Feb 21. Review. PubMed PMID: 29466611; PubMed Central PMCID: PMC6031472.

  3. Dakup PP, Porter KI, Little AA, Gajula RP, Zhang H, Skornyakov E, Kemp MG, Van Dongen HPA, Gaddameedhi S. The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models. Oncotarget. 2018 Mar 6;9(18):14524-14538. doi: 10.18632/oncotarget.24539. eCollection 2018 Mar 6. PubMed PMID: 29581861; PubMed Central PMCID: PMC5865687.

  4. Baek S, Han S, Kang D, Kemp MG*, Choi JH. Simultaneous detection of nucleotide excision repair events and apoptosis-induced DNA fragmentation in genotoxin-treated cells. Sci Rep. 2018 Feb 2;8(1):2265. doi: 10.1038/s41598-018-20527-6. PubMed PMID: 29396432; PubMed Central PMCID: PMC5797224.  (*co-corresponding author).

2017

  1. Kemp MG. DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH). J Biol Chem. 2017 Jul 28;292(30):12424-12435. doi: 10.1074/jbc.M117.788406. Epub 2017 Jun 7. PubMed PMID: 28592488; PubMed Central PMCID: PMC5535018.

  2. Kemp MG, Spandau DF, Travers JB. Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin. Molecules. 2017 Feb 26;22(3). doi: 10.3390/molecules22030356. Review. PubMed PMID: 28245638; PubMed Central PMCID: PMC5432641.

  3. Kemp MG. Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity. J Cell Death. 2017;9:1179670716685085. doi: 10.1177/1179670716685085. eCollection 2017. Review. PubMed PMID: 28469477; PubMed Central PMCID: PMC5392045.

  4. Kemp MG, Spandau DF, Simman R, Travers JB. Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes. J Biol Chem. 2017 Jan 27;292(4):1231-1239. doi: 10.1074/jbc.M116.765883. Epub 2016 Dec 15. PubMed PMID: 27979966; PubMed Central PMCID: PMC5270469.

  5. Kemp MG, Hu J. PostExcision Events in Human Nucleotide Excision Repair. Photochem Photobiol. 2017 Jan;93(1):178-191. doi: 10.1111/php.12641. Epub 2016 Oct 27. Review. PubMed PMID: 27645806; PubMed Central PMCID: PMC5315629.

  6. Song J, Kemp MG, Choi JH. Detection of the Excised, Damage-containing Oligonucleotide Products of Nucleotide Excision Repair in Human Cells. Photochem Photobiol. 2017 Jan;93(1):192-198. doi: 10.1111/php.12638. Epub 2016 Nov 3. Review. PubMed PMID: 27634428; PubMed Central PMCID: PMC5315615.

2016

  1. Canturk F, Karaman M, Selby CP, Kemp MG, Kulaksiz-Erkmen G, Hu J, Li W, Lindsey-Boltz LA, Sancar A. Nucleotide excision repair by dual incisions in plants. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4706-10. doi: 10.1073/pnas.1604097113. Epub 2016 Apr 11. PubMed PMID: 27071131; PubMed Central PMCID: PMC4855589.

  2. Kemp MG, Sancar A. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. J Biol Chem. 2016 Apr 22;291(17):9330-42. doi: 10.1074/jbc.M116.719740. Epub 2016 Mar 3. PubMed PMID: 26940878; PubMed Central PMCID: PMC4861496.

2015

  1. Lindsey-Boltz LA, Kemp MG, Hu J, Sancar A. Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair. J Biol Chem. 2015 Dec 11;290(50):29801-7. doi: 10.1074/jbc.M115.695254. Epub 2015 Oct 21. PubMed PMID: 26491008; PubMed Central PMCID: PMC4705967.

  2. Choi JH, Kim SY, Kim SK, Kemp MG, Sancar A. An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS. J Biol Chem. 2015 Nov 27;290(48):28812-21. doi: 10.1074/jbc.M115.690354. Epub 2015 Oct 5. PubMed PMID: 26438822; PubMed Central PMCID: PMC4661397.

  3. Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. EMBO J. 2015 Aug 4;34(15):2096-110. doi: 10.15252/embj.201488016. Epub 2015 Jun 16. PubMed PMID: 26082189; PubMed Central PMCID: PMC4551354.

  4. Kemp MG, Lindsey-Boltz LA, Sancar A. UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1). J Biol Chem. 2015 May 8;290(19):12184-94. doi: 10.1074/jbc.M115.649301. Epub 2015 Mar 19. PubMed PMID: 25792739; PubMed Central PMCID: PMC4424351.

  5. Gaddameedhi S, Selby CP, Kemp MG, Ye R, Sancar A. The circadian clock controls sunburn apoptosis and erythema in mouse skin. J Invest Dermatol. 2015 Apr;135(4):1119-1127. doi: 10.1038/jid.2014.508. Epub 2014 Nov 28. PubMed PMID: 25431853; PubMed Central PMCID: PMC4366313.

  6. Sancar A, Lindsey-Boltz LA, Gaddameedhi S, Selby CP, Ye R, Chiou YY, Kemp MG, Hu J, Lee JH, Ozturk N. Circadian clock, cancer, and chemotherapy. Biochemistry. 2015 Jan 20;54(2):110-23. doi: 10.1021/bi5007354. Epub 2014 Oct 29. PubMed PMID: 25302769; PubMed Central PMCID: PMC4303322.

  7. Lindsey-Boltz LA, Kemp MG, Capp C, Sancar A. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle. 2015;14(1):99-108. doi: 10.4161/15384101.2014.967076. PubMed PMID: 25602520; PubMed Central PMCID: PMC4614876.

2014

  1. Kemp MG, Gaddameedhi S, Choi JH, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014 Sep 19;289(38):26574-83. doi: 10.1074/jbc.M114.597088. Epub 2014 Aug 8. PubMed PMID: 25107903; PubMed Central PMCID: PMC4176238.

  2. Lindsey-Boltz LA, Kemp MG, Reardon JT, DeRocco V, Iyer RR, Modrich P, Sancar A. Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem. 2014 Feb 21;289(8):5074-82. doi: 10.1074/jbc.M113.542787. Epub 2014 Jan 8. PubMed PMID: 24403078; PubMed Central PMCID: PMC3931066.

  3. Choi JH, Gaddameedhi S, Kim SY, Hu J, Kemp MG, Sancar A. Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells. Nucleic Acids Res. 2014 Feb;42(4):e29. doi: 10.1093/nar/gkt1179. Epub 2013 Nov 22. PubMed PMID: 24271390; PubMed Central PMCID: PMC3936724.

2013

  1. Hu J, Choi JH, Gaddameedhi S, Kemp MG, Reardon JT, Sancar A. Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo. J Biol Chem. 2013 Jul 19;288(29):20918-26. doi: 10.1074/jbc.M113.482257. Epub 2013 Jun 8. PubMed PMID: 23749995; PubMed Central PMCID: PMC3774362.

  2. Hassan BH, Lindsey-Boltz LA, Kemp MG, Sancar A. Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response. J Biol Chem. 2013 Jun 28;288(26):18903-10. doi: 10.1074/jbc.M113.475517. Epub 2013 May 21. PubMed PMID: 23696651; PubMed Central PMCID: PMC3696666.

2012

  1. Kemp MG, Sancar A. DNA excision repair: where do all the dimers go? Cell Cycle. 2012 Aug 15;11(16):2997-3002. doi: 10.4161/cc.21126. Epub 2012 Jul 24. PubMed PMID: 22825251; PubMed Central PMCID: PMC3442910.

  2. Kemp MG, Reardon JT, Lindsey-Boltz LA, Sancar A. Mechanism of release and fate of excised oligonucleotides during nucleotide excision repair. J Biol Chem. 2012 Jun 29;287(27):22889-99. doi: 10.1074/jbc.M112.374447. Epub 2012 May 9. PubMed PMID: 22573372; PubMed Central PMCID: PMC3391136.

2011

  1. Yilmaz S, Sancar A, Kemp MG. Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. PLoS One. 2011;6(7):e22986. doi: 10.1371/journal.pone.0022986. Epub 2011 Jul 29. PubMed PMID: 21829571; PubMed Central PMCID: PMC3146532.

  2. Kemp MG, Lindsey-Boltz LA, Sancar A. The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. J Biol Chem. 2011 Jun 3;286(22):19237-46. doi: 10.1074/jbc.M111.235036. Epub 2011 Apr 12. PubMed PMID: 21487018; PubMed Central PMCID: PMC3103302.

  3. Serçin O, Kemp MG. Characterization of functional domains in human Claspin. Cell Cycle. 2011 May 15;10(10):1599-606. doi: 10.4161/cc.10.10.15562. Epub 2011 May 15. PubMed PMID: 21478680; PubMed Central PMCID: PMC3127160.

2010

  1. Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A. Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107. Epub 2010 Jun 28. PubMed PMID: 20616048; PubMed Central PMCID: PMC2922256.

  2. Gaddameedhi S, Kemp MG, Reardon JT, Shields JM, Smith-Roe SL, Kaufmann WK, Sancar A. Similar nucleotide excision repair capacity in melanocytes and melanoma cells. Cancer Res. 2010 Jun 15;70(12):4922-30. doi: 10.1158/0008-5472.CAN-10-0095. Epub 2010 May 25. PubMed PMID: 20501836; PubMed Central PMCID: PMC2891231.

  3. Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem. 2010 May 28;285(22):16562-71. doi: 10.1074/jbc.M110.110304. Epub 2010 Mar 15. PubMed PMID: 20233725; PubMed Central PMCID: PMC2878033.

  4. Chowdhury A, Liu G, Kemp M, Chen X, Katrangi N, Myers S, Ghosh M, Yao J, Gao Y, Bubulya P, Leffak M. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol. 2010 Mar;30(6):1495-507. doi: 10.1128/MCB.00710-09. Epub 2010 Jan 11. PubMed PMID: 20065034; PubMed Central PMCID: PMC2832489.

  5. Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A, Wold MS. An alternative form of replication protein a expressed in normal human tissues supports DNA repair. J Biol Chem. 2010 Feb 12;285(7):4788-97. doi: 10.1074/jbc.M109.079418. Epub 2009 Dec 7. PubMed PMID: 19996105; PubMed Central PMCID: PMC2836084.

2006-2009

  1. Kemp M, Sancar A. DNA distress: just ring 9-1-1. Curr Biol. 2009 Sep 15;19(17):R733-4. doi: 10.1016/j.cub.2009.07.026. PubMed PMID: 19833574.

  2. Kang TH, Reardon JT, Kemp M, Sancar A. Circadian oscillation of nucleotide excision repair in mammalian brain. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2864-7. doi: 10.1073/pnas.0812638106. Epub 2009 Jan 21. PubMed PMID: 19164551; PubMed Central PMCID: PMC2629438.

  3. Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK. Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B. J Biol Chem. 2007 Apr 6;282(14):10441-8. doi: 10.1074/jbc.M609632200. Epub 2007 Jan 30. PubMed PMID: 17264083.

  4. Ghosh M, Kemp M, Liu G, Ritzi M, Schepers A, Leffak M. Differential binding of replication proteins across the human c-myc replicator. Mol Cell Biol. 2006 Jul;26(14):5270-83. doi: 10.1128/MCB.02137-05. PubMed PMID: 16809765; PubMed Central PMCID: PMC1592723.

  5. Casper JM, Kemp MG, Ghosh M, Randall GM, Vaillant A, Leffak M. The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro. J Biol Chem. 2005 Apr 1;280(13):13071-83. doi: 10.1074/jbc.M404754200. Epub 2005 Jan 14. PubMed PMID: 15653697.

  6. Kemp MG, Ghosh M, Liu G, Leffak M. The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. Nucleic Acids Res. 2005;33(1):325-36. doi: 10.1093/nar/gki177. Print 2005. PubMed PMID: 15653633; PubMed Central PMCID: PMC546162.

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